The management of menopause and its symptoms was improved significantly after the advent of hormone replacement therapy. With synthetic or semisynthetic hormones symptoms abated, management was made easy.

Then the Women Health Initiative Study results came out. They found that hormone replacement theraly (HRT) increased risks of heart disease, formation of blood clots, and breast cancer. Hormones used in WHI, were conjugated (horse) estrogens and progestins (a synthetic progesterone). The other statistics confirm these findings. For example, they found that the breast

cancer rate in the US is declining because of cutting down on HRT.

The problem with synthetic or semisynthetic hormones is utilization: our body does not know what to do with them. But our body knows exactly what to do with our own hormones. An example: natural estrogen is metabolized by the 2-OH pathway, which creates benign waste products. Conjugated (horse) estrogen is metabolized by the 4-OH pathway, which isn’t natural. The result: byproducts that were linked to cancer.

We use the hormones with the same chemical structures as our own, as well as transdermal use to bypass the liver. We avoid synthetic or semisynthetic hormones.

Do we have controlled double blind studies to confirm the safety and effectiveness of the bioidentical hormones, which have the same molecular structure as our own? No, and we won't have any either -- at least in the near future. Substances which occur in nature can’t be patented. Therefore, there isn’t any money to subsidize the studies. Do we really need them? The effectiveness of insulin was confirmed on 1 patient after he was injected with pancreatic extract, and his blood sugar level decreased. The power of vaccination was confirmed on only 21 patients, without double blind studies. Would we get insulin or vaccines if double blind studies were required?

Our experiences show that hormones with the same molecular structure as our own are effective for hormone replacement therapy, if used correctly under appropriately trained physician’s supervision. We know that they’re working for menopause and andropause. Do we have to wait until future studies come out?

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